用于脑血流自调节功能评估的生物阻抗技术研究
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TH789

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国家自然科学基金(52077143)、辽宁省自然科学基金计划(2019-ZD-0204)、辽宁省教育厅重点攻关项目(LZGD2020002)资助


Study on bioimpedance technique for the evaluation of cerebral blood flow autoregulation function
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    摘要:

    脑血流自动调节(CAR)是血管在神经控制下进行的脑部供血调节过程,通过评估 CAR 可以判断大脑神经和生理状态。 本文对脑生物阻抗检测技术评估大脑自调节进行了研究,在脑血流自调节评估中引进脑血流循环阻力参数和动脉血管弹性参 数。 在实验中使用干预措施使受试者脑供血系统处于正常调节状态和失常状态。 分别测量两种状态下的脑血流阻抗信号,提 取阻力参数与弹性参数。 对比分析表明血管弹性参数和血流阻力参数变化比分别为 8. 53% 和 20. 89% ,统计学分析显示两个参 数在干预前后均存在显著性差异(P<0. 001)。 实验验证了脑血流生物阻抗检测可以跟踪脑血流自调节的变化过程,该方法对 脑部生理活动和脑神经功能生物阻抗检测的进一步研究具有重要意义。

    Abstract:

    The cerebral blood flow autoregulation (CAR) is the brain blood supply regulation process of brain vessel under the control of nerve. The nerve and physiological states of the brain can be judged through evaluating the CAR. In this paper, using bioimpedance technique to evaluate CAR is studied. The brain blood flow circulating resistance parameter and artery blood vessel elasticity parameter are introduced in the CAR evaluation. In the experiment, the intervene method was used to make the brain blood supply system of the subjects in normal and abnormal states. The brain blood flow impedance signals were measured in the two states, and the resistance parameter and elasticity parameter were extracted. Comparative analysis shows that the change ratios of the resistance and elasticity parameters are 8. 53% and 20. 89% , respectively. Statistical analysis shows that these two parameters have significant difference (P< 0. 001) before and after the intervention. The experiment results verify that the brain blood flow bioimpedance technique can track the change process of CAR, and the proposed method has great significance for the further study of brain physiological activity and brain nerve function using bioimpedance detection.

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陈 佳,柯 丽,杜 强,颜莹莹.用于脑血流自调节功能评估的生物阻抗技术研究[J].仪器仪表学报,2021,(2):189-196

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  • 在线发布日期: 2023-06-28
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