High temperature strain gauge is an important research assurance for aero-engines. To meet its higher use requirements, the structural parameters of high temperature strain gauge sensitive grid are optimized. Firstly, the influence of wire length, wire spacing and wire bending number on the measurement error and fatigue life of sensitive grid is analyzed by the finite element method considering the temperature error. Secondly, the response surface model of measurement error and fatigue life is formulated, which is based on response surface methodology. The multi-objective gray wolf algorithm is used to perform the structural parameter optimization, and the Pareto optimal solution set is obtained. Finally, according to the optimization results, a high temperature strain gauge is prepared for high temperature vibration fatigue test. The simulation results show that the sensitive grid structure with different parameter combinations has different effects on the performance of the high temperature strain gauge. The Pareto optimal solution set is evaluated by comparing the production requirements and performance of the high temperature strain gauge, and an optimal sensitive grid structure is obtained. The fatigue life of the optimized strain gauge at high temperature is increased by 30. 4% compared with that before optimization, and the optimization effect is remarkable.